The purpose of this study was to assess the differences in self esteem and general psychological well-being including levels of autonomy, personal growth and self-acceptance between working women and non-working women. The sample consisted of randomly selected 101 Lebanese women between 250and 55 years old. The Rosenberg Self-Esteem Scale and the Ryff's Scales of Psychological Well-Being were the two tools used in this study. This study was a quantitative study that utilized the t-test, as well as the method of correlation and simple percentages. The results were significant and showed that working women score higher on the Self-Esteem Scale and the Ryff's Scales of Psychological Well-Being as well as the subscales, personal growth, self-acceptance and autonomy. This study confirmed the importance of work in increasing levels of self-esteem and psychological well-being among Lebanese women.